Endocrine Abstracts

Yu Pei and Sanjiv Risal are joint first authors. Elisabet Stener-Victorin and Qiaolin Deng are joint corresponding authors. Polycystic ovary syndrome (PCOS) affects around 15% of women of reproductive age and the key feature of the syndrome is hyperandrogenism. To understand the complex pathophysiology of PCOS, more than 30 PCOS-like animal models have been developed to mimic certain pathophysiological features. So far, not much is known about the common and unique molecular a...

Introduction: The hyperandrogenic in utero environment in pregnant women with polycystic ovary syndrome (PCOS) can affect embryo development and impair offspring health at adult age. Moreover, long term hyperandrogenic exposure also leads to unfavored changes to the mothers’ reproductive physiology, leading to miscarriage, preterm delivery, and perinatal mortality. The underlying mechanism(s) of pregnancy complications associated with PCOS and the consequence of ...